SERVICE · TARGET DISCOVERY
PortraiTARGET
From tumor-selective ADCs to dual-targeting degraders — spatial transcriptomics + AI modeling + multi-dimensional validation reveal targets standard pipelines miss.
Revolutionizing drug discovery with Spatial Omics and AI-driven Virtual Tissue Pharmacology
A unified, AI-driven decision platform. We integrate one of the most comprehensive spatial transcriptomics datasets with in-silico prediction and rigorous validation to accelerate therapeutic development.
① DATA ENGINE
PortraiATLAS
We build high-quality spatial-omics big data to precisely reconstruct the microenvironment and gene-expression patterns within human tissue.
- 2,000+
- Patient samples
- 50M+
- Spatially resolved cells
- 7+
- Cancer types (NSCLC, SCLC, BRCA, COAD, PRAD, RCC, ESCA)
② PREDICTION ENGINE
Virtual Tissue Pharmacology
Before dosing real patients, we precisely predict drug distribution (Microscopic-PK) and cellular response (Microscopic-PD) on virtual tissue, in silico.
SERVICE · DRUG DISTRIBUTION
PortraiDRUG / PortraiMIX
Quantify drug distribution and mechanism-of-action in tissue via spatial transcriptomics. Applies to ADCs, mRNA, stem cell, and combination therapies.
Virtual Spatial Omics
VGL Suite
An AI model that generates virtual spatial-omics (Virtual ST) data from H&E tissue images and clinical metadata.
Drug Distribution Simulation
Microscopic-PK
Quantitatively tracks where, how much, and how long a drug stays as it moves through the tissue microenvironment and vasculature (Drug Distribution Map).
Cellular Response Prediction
Microscopic-PD
Spatially predicts per-cell sensitivity, death, and gene-expression changes in response to drug concentration (Drug Action Map).
③ VALIDATION ENGINE
Translational PoC
Using AI predictions, we derive the optimal dose, payload, and indication priority to validate a drug's value.
- 01IN-SILICO
AI Prediction
Decode TME architecture, predict payload accumulation and off-target risks computationally.
- 02WET-LAB
Parallel Validation
Validate ADCs & modality candidates in vitro. Spatial transcriptomics confirms co-localization.
- 03IN-VIVO
Pre-clinical Imaging
POR006 and RPT assets advance to pre-clinical imaging and human imaging stages.
PRODUCT LINEUP
The Portrai product lineup
Drug Discovery / Translational
PortraiTARGET
Therapeutic target discovery for ADCs, RPTs, bispecifics.
Drug Discovery / Translational
PortraiDRUG / PortraiMIX
Drug distribution visualization and label-free spatial transcriptomics.
Drug Discovery / Translational
PortraiMOA
Drug mechanism-of-action analysis.
AI & Prediction Models
VGL Suite
An AI model that generates virtual spatial-omics (Virtual ST) data from H&E tissue images and clinical metadata.
AI & Prediction Models
Microscopic-PK
Quantitatively tracks where, how much, and how long a drug stays across the tissue microenvironment and vasculature (Drug Distribution Map).
AI & Prediction Models
Microscopic-PD
Spatially predicts per-cell sensitivity, death, and gene-expression changes by drug concentration (Drug Action Map).
Spatial Intelligence Software Platform
Portrai Insilicolab™
A SaaS web platform providing spatial-omics data visualization and AI analysis.
- Portrai ExplorerLarge-scale visualization and exploration of spatial-omics data.
- PortrAIgentAI-powered automated interpretation and analysis assistant.
VALUE FOR PARTNERS
Accelerated by Portrai
Co-Discovery Partnerships
Collaborate with us to discover and validate novel targets using one of the largest spatial transcriptomics databases in oncology.
Asset Licensing
Access de-risked pre-clinical pipeline assets (POR-series) for rapid clinical advancement.
Infrastructure
Supported by global technology partners for secure, scalable spatial data computing.
READY TO ACCELERATE?
Ready to accelerate your pipeline?
See how Portrai's platform can de-risk drug discovery from spatial insights to life-changing therapies.