PRODUCT · SERVICE PLATFORM
PortraiDRUG / PortraiMIX
See where your therapy goes — and what it really does — without a label.
Label-free spatial transcriptomics for next-generation therapeutics. Trace mRNA, cell, gene, and microbiome therapies inside real tissue — using the transcriptome itself as the reporter, no fluorescent tag or genetic edit required.
- MODALITY COVERAGE
- mRNA · Cell · Gene · Microbiome
- READOUT
- Spatial distribution + degradation + MoA
- PEER-REVIEWED
- Park et al. Advanced Therapeutics 2023
WHY PORTRAIMIX
Drop the label. Keep the biology.
Fluorescent tags and genetic edits change the very therapy you're trying to study. PortraiMIX uses the transcriptome itself as a reporter — so the molecule you observe is the molecule you'll actually ship.
- 01
Truly label-free
No fluorescent tagging, no genetic engineering of the therapy. The transcriptome itself reports where the molecule went and what changed around it.
- 02
Multi-modal coverage
One method handles mRNA / LNP, stem-cell engraftment, gene therapy, microbiome agents, and combination regimens — without re-tooling the assay for each modality.
- 03
Microenvironment-level insight
Spatially resolved mechanism, immune interactions, and therapeutic outcomes — not bulk averages. Built on peer-reviewed methods (Park et al. Advanced Therapeutics 2023).
WHAT IT DOES
From delivery to mechanism, on real tissue
Six analyses on one platform — covering tracing, engraftment, microbial mapping, comparative MoA, deconvolution, and RNA modification.
- Delivery readout
mRNA tracing & degradation
Trace exogenously delivered mRNA (e.g., LNP-formulated therapeutics), quantify spatial distribution and degradation, and measure translational efficiency.
- Engraftment
Species-specific transcript separation
Assess human cell engraftment in xenograft or immunocompromised models with robust separation of human vs host transcripts at single-spot resolution.
- Microbial therapy
Microbiome spatial mapping
Visualize microbiome-based therapeutics within host tissues, identify spatially relevant biomarkers, and surface immunological shifts driven by live microbial agents.
- Mechanism
Comparative MoA analysis
Run deep comparative analysis across treatment arms to elucidate biological processes and mechanism of action — not just a single endpoint.
- Cell-type resolution
Tissue-specific clustering & deconvolution
Cluster spots by tissue context and deconvolve cell-type composition to read therapeutic effect at cell-type resolution within real microenvironments.
- Beyond expression
RNA modification mapping
Map RNA modifications spatially — capture biology that pure expression-level readouts miss, including post-transcriptional regulation in situ.
MODALITIES
Built for the next-generation modalities
Modalities that don't fit a fluorescent tag — or where tagging would distort the biology — read cleanly on the same platform.
mRNA / LNP
Spatial distribution and degradation kinetics of LNP-formulated mRNA, with translational efficiency mapped onto real tissue.
Cell therapy
Stem-cell and xenograft engraftment readouts via species-specific transcripts — engrafted cells are detected without genetic labels.
Gene therapy
Track delivery and downstream transcriptional response across vectors and tissues — deconvolved at cell-type resolution.
Microbiome / Combination
Live microbial agents in host tissues; combination regimens (ADC + immunomodulator, mRNA + cell therapy) read on a single platform.
USE CASES
Validated use cases
Three programs already accelerated by PortraiMIX in partner pipelines.
mRNA gene therapy
Quantifies LNP delivery, spatial degradation, and translational efficiency — so dose, formulation, and route can be optimized against real tissue distribution.
Cell therapy
Detects human stem cells in treated joints and correlates engraftment with localized biological activation — an engraftment readout without genetic labels.
Microbiome therapy
Tracks live microbial agents inside host tissue and quantifies their influence on immune response — at spatial resolution, in real microenvironments.
READY TO SEE THE BIOLOGY?
See your therapy differently — no label required.
PortraiMIX is already accelerating discovery for biotech and pharma teams across the globe. Talk to our BD team to start a project or request a live demo.