포트래이 인사이트
데이터 분석과 AI 기술, 그리고 포트래이가 만들어가는 플랫폼의 생각을 전합니다.
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[Sid’s Data Journey - Part 3] Virtual Tissue Pharmacology: Bringing In Silico Drug Testing to a Patient Tissue
The AI scientist in the loop Two things happen in this part. We turn expression into radiation dose, which is the number aradiopharmaceutical is actually judged on. And we show who did the first vers…
[Sid’s Data Journey - Part 2] Beyond Expression: How to Evaluate Drug Targets
Does it hit every cancer cell A target that reaches only a fraction of a tumour inevitably leaves part of it behind. That is why coverage—the fraction of cancer cells expressing a target—is one of th…
[Sid’s Data Journey - Part 1] Single-Patient PortraiTARGET: Data-Driven Target Discovery for Personalized Drug Development
One patient is a dataset single-patient target discovery with PortraiTARGET Portrai is building PortraiTARGET, a platform designed to identify the best targets for cancerdrugs by analyzing large-scal…
Target-based Understanding the Termination of the AMG 794 Clinical Trial: A Deep Dive with spatial transcriptomics data
Amgen has exited the competitive development of Claudin 6 (CLDN6) therapies, which is still in its early stages, based on initial data from preclinical studies. Amgen, on July 5th 2024, had terminate…
Engineering and evaluation of precision-glycosylated clickable albumin nanoplatform for targeting the tumor microenvironment
doi: https://doi.org/10.7150/thno.123973 https://www.thno.org/ms/acceptms Abstract Rationale: Glycosylation of drug delivery vehicles enables selective tumor microenvironment (TME) targeting but is l…
포트래이-
Spatial transcriptomics unveils landscape of resistance to concurrent chemo-radiotherapy in hypopharyngeal squamous cell carcinoma: the role of SPP1+ macrophages
doi: https://doi.org/10.1101/2024.07.09.602476 Abstract Hypopharyngeal squamous cell carcinoma (SCC) is a highly aggressive cancer with a poor prognosis, particularly in advanced stages where concurr…
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Analysis of Unmapped RNA-seq Data from Cancer Spatial Transcriptome to Decipher Cancer Microbiome
doi: https://doi.org/10.1101/2024.06.09.598160 Abstract Recent research increasingly emphasizes the importance of the microbiome in the development and progression of cancer. Thus, exploring the micr…
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Spatial Transcriptomics Reveals Spatially Diverse Cancer-Associated Fibroblast in Lung Squamous Cell Carcinoma Linked to Tumor Progression
doi: https://doi.org/10.1101/2024.05.16.594592 Abstract While cancer-associated fibroblasts (CAFs) are crucial in influencing tumor growth and immune responses in lung cancer, we still lack a compreh…
포트래이-
CELLama: Foundation Model for Single Cell and Spatial Transcriptomics by Cell Embedding Leveraging Language Model Abilities
doi: https://doi.org/10.1101/2024.05.08.593094 Abstract Large-scale single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) have transformed biomedical research into a data-driven fie…
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