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Journal articles

Comprehensive gene expression analysis for exploring the association between glucose metabolism and differentiation of thyroid cancer

BMC Cancer. 2019;19(1):1260. Abstract Background: The principle of loss of iodine uptake and increased glucose metabolism according to dedifferentiation of thyroid cancer is clinically assessed by im…

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Journal articles

A pan-cancer analysis of the clinical and genetic portraits of somatostatin receptor expressing tumor as a potential target of peptide receptor imaging and therapy

EJNMMI Res. 2020;10(1):42. Abstract Purpose: Although somatostatin receptor (SST) is a promising theranostic target and is widely expressed in tumors of various organs, the indication for therapies t…

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Journal articles

Tumor immune profiles noninvasively estimated by FDG PET with deep learning correlate with immunotherapy response in lung adenocarcinoma

Theranostics. 2020;10(23):10838–10848. Abstract The metabolic properties of tumor microenvironment (TME) are dynamically dysregulated to achieve immune escape and promote cancer cell survival. Howeve…

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Journal articles

Differences in Tumor Immune Microenvironment in Metastatic Sites of Breast Cancer

Front Oncol. 2021;11:649004. Abstract Introduction: Tumor immune microenvironment (TIME) promotes immune escape, allowing for tumor progression and metastasis. In spite of the current evidence of the…

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Journal articles

Glucose metabolic profiles evaluated by PET associated with molecular characteristic landscape of gastric cancer.

Gastric Cancer. 2021 Aug 7. doi: 10.1007/s10120–021–01223–3. Online ahead of print. Abstract Background: Although FDG-PET is widely used in cancer, its role in gastric cancer (GC) is still controvers…

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Journal articles

Alzheimer’s Disease Neuroimaging Initiative. Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer’s disease

J Neuroinflammation. 2021 Aug 31;18(1):190. Abstract Background: Dynamically altered microglia play an important role in the progression of Alzheimer’s disease (AD). Here, we found a close associatio…

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Single-cell analysis reveals the key role of enhanced endothelial glucose uptake in neurometabolic coupling

Journal of Nuclear Medicine, 61 (supplement 1) 85. Abstract Objectives: Increased glucose uptake in the activated region of the brain known as neurometabolic coupling has long been widely accepted in…

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Journal articles

Discovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients

Scientific reports, 11(1), 1–9. Abstract The Coronavirus disease 2019 (COVID-19) has been spreading worldwide with rapidly increased number of deaths. Hyperinflammation mediated by dysregulated monoc…

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Journal articles

Integrative analysis of imaging and transcriptomic data of the immune landscape associated with tumor metabolism in lung adenocarcinoma: clinical and prognostic implications.

Theranostics, 8(7), 1956. Abstract Although metabolic modulation in the tumor microenvironment (TME) is one of the key mechanisms of cancer immune escape, there is a lack of understanding of the comp…

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