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Association of metabolic and genetic heterogeneity in head and neck squamous cell carcinoma with prognostic implications: integration of FDG PET and genomic analysis
The linkage between the genetic and phenotypic heterogeneity of the tumor has not been thoroughly evaluated. Herein, we investigated how the genetic and metabolic heterogeneity features of the tumor a
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Alzheimer’s Disease Neuroimaging Initiative. Amyloid PET Quantification Via End-to-End Training of a Deep Learning
Although quantification of amyloid positron emission tomography (PET) is important for evaluating patients with cognitive impairment, its routine clinical use is hampered by complicated preprocessing
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Theranostics Based on Liposome: Looking Back and Forward.
Liposome is one of the oldest yet most successful nanomedicine platforms. Doxil®, PEGylated liposome loaded with doxorubicin (DOX), was approved by the FDA in 1995 for the treatment of AIDS-related Ka
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Versatile and Finely Tuned Albumin Nanoplatform based on Click Chemistry.
Albumin is one of the most attractive nanoplatforms for targeted imaging and drug delivery due to its biocompatibility and long circulation half-life. However, previously reported albumin-based nanopl
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Deep learning only by normal brain PET identify unheralded brain anomalies
Recent deep learning models have shown remarkable accuracy for the diagnostic classification. However, they have limitations in clinical application due to the gap between the training cohorts and rea
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Development of 99mTc-Labeled Human Serum Albumin with Prolonged Circulation by Chelate-then-Click Approach: A Potential Blood Pool Imaging Agent.
Technetium-99m-labeled human serum albumin (99mTc-HSA) has been utilized as a blood pool imaging agent in the clinic for several decades. However, 99mTc-HSA has a short circulation time, which is a cr
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DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury
Patients with acute kidney injury (AKI) frequently require kidney transplantation and supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled DNA origami nanostructure
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Predicting Aging of Brain Metabolic Topography Using Variational Autoencoder
Predicting future brain topography can give insight into neural correlates of aging and neurodegeneration. Due to variability in the aging process, it has been challenging to precisely estimate brain
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Generation of structural MR images from amyloid PET: Application to MR-less quantification
Structural MR images concomitantly acquired with PET images can provide crucial anatomic information for precise quantitative analysis. However, in the clinical setting, not all the subjects have corr
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