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Peptide-based theranostics targeting ANTXR1 in cancer stroma
NTXR1 is one of the pancreatic ductal adenocarcinoma (PDAC) stroma-specific cell surface markers (Ref 1), which is also overexpressed in the stroma of various cancer types. Radiotheranostics refers...
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Mapping cell types in the tumor microenvironment from tissue images via deep learning trained by spatial transcriptomics of lung adenocarcinoma
Profiling heterogeneous cell types in the tumor microenvironment (TME) is important for cancer immunotherapy.
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GeneDART: Extending gene coverage in image-based spatial transcriptomics by deep learning-based domain adaptation with barcode-based RNA-sequencing data
Spatial transcriptomics (ST) technologies provide comprehensive biological insights regarding cell-cell interactions and peri-cellular…
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STopover captures spatial colocalization and interaction in the tumor microenvironment using topological analysis in spatial transcriptomics data
Unraveling the spatial configuration of the tumor microenvironment (TME) is key to understanding tumor-immune interactions to translate them…
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Discovery of stromal targets in pancreatic cancer Available
-5007-Discovery-of-stromal-targets-in Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the…
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Deep learning-based tumor microenvironment cell types mapping from H&E images of lung adenocarcinoma using spatial transcriptomic data
Spatial characterization of cell types of the tumor microenvironment (TME) is a key to finding new targets as well as developing biomarkers for immuno-oncology treatment. Here, we develop and validate
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Spatial Transcriptomics-based Identification of Molecular Markers for Nanomedicine Distribution in Tumor Tissue
The intratumoral accumulation of nanomedicine has been considered a passive process, referred to as the enhanced permeability and retention…
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CellDART: cell type inference by domain adaptation of single-cell and spatial transcriptomic data
Deciphering the cellular composition in genome-wide spatially resolved transcriptomic data is a critical task to clarify the spatial context of cells in a…
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Alzheimer’s Disease Neuroimaging Initiative. Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer’s disease
Dynamically altered microglia play an important role in the progression of Alzheimer’s disease (AD).
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