Portrai Insights
Insights on data analysis, AI, and the platform we're building at Portrai.
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17 articles
Development of human antibodies targeting a novel cancer-associated fibroblast protein identified from spatial transcriptomics
Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment and play a critical role in tumor progression and therapy resistance. Recent advances in spatial transcriptomics..
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High-resolution AI-based spatial biology tool for lung cancer trained by image-based spatial transcriptomics data to analyze tumor microenvironmnet
Spatial biology enables the analysis of tumor microenvironments by revealing cellular relationships within the heterogeneous tumor landscape, which are closely associated with tumor characteristics...
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Biologically informed cell typing in the tumor microenvironment with lightweight LLMs
The tumor microenvironment (TME) is a complex ecosystem of diverse cell types that interact dynamically, influencing tumor development and therapy response. Accurate cell type annotation in the TME...
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Estimation of homologous recombination deficiency map from spatial transcriptomics
Homologous recombination deficiency (HRD) is a predictive biomarker for various anti-cancer drugs such as poly(ADP-ribose) polymerase inhibitors (PARPi) and platinum-based chemotherapeutic agents...
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Unveiling the tumor microenvironment of hepatocellular carcinoma using AI trained by spatial transcriptomics: A preliminary study to predict response to immunotherapy
Immune checkpoint inhibitors (ICIs), particularly targeting the PD-1 pathway, are promising in treating hepatocellular carcinoma (HCC). However, their variable effectiveness among individuals calls...
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Cancer region definition using spatial gene expression patterns by super resolution reconstruction algorithm for spatial transcriptomics data
Spatially resolved transcriptomics (ST) has enabled a variety of cancer research on the heterogeneity of tumor microenvironment. However, when identifying cancer boundaries based on ST, the limited...
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IAMSAM: Image-based analysis of molecular signatures using the Segment-anything model - Integrative analysis tool for tumor microenvironment
Spatial transcriptomics (ST) is a powerful approach for investigating gene expression patterns in tissues while preserving their spatial context. However, working with ST data presents challenges...
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Comparative spatial transcriptomic analysis of monoclonal antibodies targeting the same molecule: A comparison between cetuximab and panitumumab
In recent years, multiple therapeutic monoclonal antibodies have been developed that target the same molecules. Examples include trastuzumab and pertuzumab for HER2, cetuximab (CTX) and panitumumab...
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Automated tumor microenvironment analysis for multiple samples by image-based spatial transcriptomics on tissue microarray
Tissue Microarrays (TMAs), widely utilized in the field of pathology, have now found a powerful ally in Image-based Spatial Transcriptomics (ST). By analyzing various gene expression data with high...
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Portrai's Authors
Capturing and compounding Portrai's insights.
Daeseung Lee
CEO
Physician-scientist who left clinical practice to bring spatial biology into oncology drug discovery
Hongyoon Choi
CTO
Builds the algorithms that turn spatial transcriptomics into actionable target intelligence
Hyung-Jun Im
CSO
Nuclear medicine specialist linking imaging biomarkers to next-generation radiopharmaceuticals
Kwonjoong Na
CMO
Translates platform insights into IND-enabling decisions across oncology programs
Portrai
Official posts from the Portrai team, decoding disease with spatial intelligence