Portrai Insights
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Showing articles by Kwonjoong Na
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7 articles
The Spatial Requirement for Digital Twins: Why Virtual Patients Need an ‘Address’
The Virtual Patient Is Coming In October 2025, SOPHiA GENETICS launched an AI-powered digital twin platform — SOPHiA DDM Digital Twins.
The Spatial Anatomy of Immunotherapy Resistance: Why Checkpoint Inhibitors Stall
Immune Cells Are There — So Why Aren't They Working? Immune checkpoint inhibitors (ICIs) have transformed the landscape of oncology.
On-Target Off-Tumor: Recalculating the Therapeutic Index of Drugs Through Spatial Biology
The cruelest paradox in drug development is that the more effective a drug, the stronger its toxicity can be. Take ADCs (antibody-drug conjugates) as an example. ADCs are designed to deliver...
From AACR 2026: Spatial Biology Is No Longer a Variable — It Is a Constant
What I Confirmed in San Diego Last week, I attended the AACR 2026 Annual Meeting. Every year when I attend this conference, I carry one question with me: "Where does spatial biology stand right now?"
Same Target, Different Destiny: The Spatial Pharmacology of ADCs
Knocking on the Same Target — Why Do the Results Differ? Antibody-drug conjugates (ADCs) are the hottest modality in cancer treatment right now.
20 µm Distance and 150 µm Boundary: When Spatial Metrics Split Treatment Response
Returning to “Same Stage, Different Destiny” In my previous post, I wrote that TNM staging is an excellent method of assessment, but it cannot fully describe the blueprint of a tumor—namely, the…
Same Stage, Different Fates: Beyond TNM Staging, What Spatial Biology Reveals About Cancer
Where Does the Uncertainty for Patients and Physicians Come From? For physicians treating cancer in clinical practice, the most difficult moment is not necessarily when surgery technically fails.
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Portrai's Authors
Capturing and compounding Portrai's insights.
Daeseung Lee
CEO
Physician-scientist who left clinical practice to bring spatial biology into oncology drug discovery
Hongyoon Choi
CTO
Builds the algorithms that turn spatial transcriptomics into actionable target intelligence
Hyung-Jun Im
CSO
Nuclear medicine specialist linking imaging biomarkers to next-generation radiopharmaceuticals
Kwonjoong Na
CMO
Translates platform insights into IND-enabling decisions across oncology programs
Portrai
Official posts from the Portrai team, decoding disease with spatial intelligence