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Portrai Insights

Insights on data analysis, AI, and the platform we're building at Portrai.

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96 articles
Journal articles

Integrative analysis of imaging and transcriptomic data of the immune landscape associated with tumor metabolism in lung adenocarcinoma: clinical and prognostic implications.

Although metabolic modulation in the tumor microenvironment (TME) is one of the key mechanisms of cancer immune escape, there is a lack of understanding of the…

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Journal articles

SpatialSPM: Statistical parametric mapping for the comparison of gene expression pattern images in multiple spatial transcriptomic datasets

Spatial transcriptomic (ST) techniques help us understand the gene expression levels in specific parts of tissues and organs, providing…

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Journal articles

A Spatial Transcriptomics based Label-Free Method for Assessment of Human Stem Cell Distribution and Effects in a Mouse Model of Lung Fibrosis

Recently, cell therapy has emerged as a promising treatment option for various disorders.

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Journal articles

IAMSAM : Image-based Analysis of Molecular signatures using the Segment-Anything Model

Spatial transcriptomics is a cutting-edge technique that combines gene expression data with spatial information, allowing researchers to…

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AACR

Deep learning-based mapping of tertiary lymphoid structure scores from H&E images of renal cell carcinoma trained by spatial transcriptomics data

Tertiary lymphoid structures are organized aggregates of immune cells present in the tumor microenvironment (TME) in which novel targets as well as beneficial biomarkers for immunotherapy in cancer...

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AACR

Peptide-based theranostics targeting ANTXR1 in cancer stroma Available

ANTXR1 is one of the pancreatic ductal adenocarcinoma (PDAC) stroma-specific cell surface markers (Ref 1), which is also overexpressed in the stroma of various cancer types. Radiotheranostics refers..

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Journal articles

Mapping cell types in the tumor microenvironment from tissue images via deep learning trained by spatial transcriptomics of lung adenocarcinoma

Profiling heterogeneous cell types in the tumor microenvironment (TME) is important for cancer immunotherapy.

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Journal articles

GeneDART: Extending gene coverage in image-based spatial transcriptomics by deep learning-based domain adaptation with barcode-based RNA-sequencing data

Spatial transcriptomics (ST) technologies provide comprehensive biological insights regarding cell-cell interactions and peri-cellular…

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Journal articles

STopover captures spatial colocalization and interaction in the tumor microenvironment using topological analysis in spatial transcriptomics data

Unraveling the spatial configuration of the tumor microenvironment (TME) is key to understanding tumor-immune interactions to translate them…

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